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Common Solvents (Volatile Organic Compounds-VOC’s) and Their Health Hazards

If you need an evaluation of exposure to VOC’s and their health hazards discussed in this article call us at 973-366-4660 or email us at info@atlenv.com for details and a free estimate.

Written by Robert E. Sheriff, MS, CIH, CSP, President

November 7, 2018; Updated October 2019; August 2021

Are All Volatile Organic Compounds (VOC’s) Hazardous to Health?

Are Mineral Spirits, Stoddard Solvent, Petroleum Distillates, Petroleum Naphtha, Turpentine, Painter’s Naphtha, VM&P Naphtha, Acetone, Lacquer Thinner, Isopropyl Alcohol, Toluene, Methyl Alcohol, and Xylene all the same? Are they hazardous?

The answer is NO and YES!

No, they are not the same because each one is chemically different.

However, they are the same because they are all hazardous to some degree if ingested, inhaled, or to a lesser degree, if they are absorbed through the skin. The following is a summary of the hazards of each solvent:

Mineral Spirits is probably the most common solvent but the same chemical mixture of hydrocarbons is often referred to as Stoddard Solvent, Petroleum Distillates, Petroleum Naphtha or White Spirits. Mineral Spirits are often used for thinning oil-based paints, cleaning brushes and cleaning and/or degreasing machine and auto parts. There are several types of mineral spirits since it is not a specific chemical but a combination of hydrocarbons. These combinations usually have sulfur removed by distillation and other distillations are intended to remove the odors and aromatic hydrocarbons—the most hazardous of which is benzene. Mineral Spirits can remove protective skin oils and increase the possibility of dermatitis or rash. Most importantly, they are dangerous if ingested because they can aspire into the lungs. Inhalation of higher concentrations of Mineral Spirits can result in respiratory irritation or even pulmonary edema as well. The possibility of any severe health effects due to exposure to Mineral Spirits is remote under normal use but care should always be taken to protect skin and lungs where use is lengthy or extreme. It should also be noted Mineral Spirits are generally called White Spirits in locations outside of the United States.

VM&P Naphtha refers to a paint thinner/cleaner and solvent whose formal name is Varnish Makers and Painter Naphtha = thus VM&P Naphtha. This is generally a lighter, more volatile solvent than Mineral Spirits. The lighter hydrocarbons are called Aliphatic hydrocarbons. These lighter hydrocarbons are more hazardous than the heavier ones in solvents like Mineral Spirits because  they evaporate faster. This allows them to be inhaled in greater concentrations which can cause more significant damage to our lungs, liver, kidneys and even skin.

Lacquer Thinners are solvent mixtures used to dilute or dissolve certain plastics and resins. They can be a combination of a variety of chemicals such as ketones, alkyl esters, and aromatic hydrocarbons. These can be more toxic than the previously mentioned solvents if they are inhaled or, ingested or if they come in contact with the skin. The good thing about lacquer thinners is that current efforts to reduce Volatile Organic Compounds (VOCs) to protect the environment has resulted in a reduction of these bad VOCs with friendlier—less toxic—VOC’s such as ethylene glycol (antifreeze) and other natural esters from plants. It is important to note that the danger of ethylene glycol is that it has a sweet taste thus possibly a serious threat to young children and animals. Such ingestion which includes aspiration into the lungs can be fatal!

Painters’ Naphtha is usually a solvent similar to Mineral Spirits that is used to dilute oil-based paint, clean brushes, and flush out paint-spraying equipment which is also called VM&P Naphtha.

Turpentine is something totally different from Mineral Spirits, Naphtha, and Petroleum Distillates in that turpentine is extracted from live trees—usually pine trees. Live trees have their trunks scored and these trees secrete a thick liquid designed to cover the tree wound. This secretion is collected and distilled to produce a special solvent. It is used as an oil paint thinner, varnish thinner and cleaner. Turpentine is much more likely to be a skin irritant if it is absorbed through intact skin. The vapors are more likely to irritate the eyes, throat, and lungs. If high or prolonged exposure occurs, turpentine is also more likely to result in kidney damage. Further, it is highly poisonous if ingested—possibly fatal—even in small amounts.

Isopropyl Alcohol (also called isopropanol) is the very common rubbing alcohol and is a common solvent for personal use, as well as light industrial uses. It evaporates quite rapidly so it is often used as a disinfectant and a cleaning agent and is water-soluble. It is even used to solubilize water in gasoline and referred to as a “gasoline dryer.” Although isopropanol is not highly toxic, it is a poison when ingested. Because it evaporates rapidly, inhalation should be minimized. If used for parts cleaning in industry, good ventilation is required and respiratory protection is often required as well. In fact, if it is used  anywhere on a regular basis, continuous efforts should be made to minimize inhalation within the industry.

Methyl Alcohol (also called methanol) is an alcohol similar to isopropanol in its evaporation rate. It used to be called “wood alcohol” because it was commonly distilled from wood but now it is made commercially by combining carbon monoxide and hydrogen. It can be used as a cleaning agent due to its water solubility but more toxic than isopropanol so the latter is often preferred. Further more, it is not generally available for personal use because it is quite poisonous. Its main uses are as an anti-freeze, paint thinner, paint remover, and even as a windshield wiper fluid. Ingestion can result in damage to multiple organs including blindness. In an industry where methanol is made or packaged, ingestion or inhalation must be minimized. This is often through complete containment in a closed system for industrial uses. Essentially, wherever methanol is used, ventilation, prevention of ingestion, and respiratory protection are critical.

Toluene- OSHA says this is the most frequently sampled chemical in the American workplace. It is an aromatic hydrocarbon, or a benzene ring with 1 methyl group. It is colorless and has a paint-thinner smell. It is a common industrial feed-stock, paint thinner, and is often contained in printing inks, airplane glue, and adhesives. Additionally, it is used in many chemical reactors. It is considered to be toxic and is specifically regulated by OSHA. The 8-hr permissible exposure level (PEL) is 200 ppm, but ACGIH recommends an 8-hr time-weighted average (TWA) of 20 ppm. Toluene exposure is to be minimized for pregnant individuals or those intending to become pregnant as well.

Acetone is a very volatile chemical that has both personal and commercial uses. It is the main ingredient in nail polish remover and is also used in fast-drying nail polishes. It has a strong odor which is mainly due to its fast evaporation rate. It is the simplest form of a group of chemicals called ketones but isn’t as toxic or hazardous as most other ketones. What is unusual is that our body produces it and disposes of it as a normal process. People who are diabetic generally produce more of it which can lead to ketoacidosis. Exposure to acetone should be avoided by those who are pregnant or intend to become pregnant since it has been shown to have some ability to cause negative reproductive effects. In industry, it is often used as a paint solvent, paint thinner, and degreasing agent, but sometimes it’s included in some medical situations since it can be cooled without freezing. It has other medical uses as well. Acetone is also used as a base chemical in many chemical reactions. Its main hazard is its flammability. Because it evaporates so fast, it can easily reach a combustible/flammable stage. Since it is not highly toxic, there are only a few cases where ventilation is necessary except to control its flammability. Respiratory protection is usually not recommended because the filters (usually charcoal) get filled up so rapidly.

Xylene is also a relatively common solvent in many commercial and industrial uses. It is also an aromatic hydrocarbon with a benzene ring base. There are only limited cases where xylene can present an overexposure situation in its commercial uses. Because it is not very volatile, it is difficult to create enough airborne xylene to exceed safe worker exposure levels. Respiratory protection is an effective means of controlling worker exposure to any of the 3 different forms of xylene (o, m, p, xylene).

These are just a very few of the solvents available. There is a vast variety of other solvent-type chemicals used in industry including coatings, degreasers, resins, solvents, inks, paints, and those used in chemical reactions. Those used in chemical reactions often tend to be equally toxic or more toxic than the mere common chemicals discussed in this article. The hazardous characteristics of these chemicals are generally known but the combination and mixtures cause considerable concern because of the possible cumulative and synergistic effects of a blend of such chemicals.

The first line of defense is to request a Safety Data Sheet (SDS) in the workplace whether you are a consumer or an industrial user of such solvents and chemicals. The next step is to get assistance from an Industrial Hygienist, Toxicologist, or another qualified expert to interpret the possible effects of the chemical combinations and the protections needed to handle them safely.



  1. McCann, M. (Ph.D., CIH), “Health Hazards of Solvents,” Health Hazards Manual for Artists, 4th Edition, Lyons and Burford, New York (1994).
  2. NJ Department of Health Hazardous Substances Fact Sheet, “Stoddard Solvent,” Revised January 2008, www.nj.gov/health/eoh/rtkweb/documents/fs/1736.pdf.
  3. NIOSH Pocket Guide to Chemical Hazards, “VM&P Naphtha,” Centers for Disease Control and Prevention, www.cdc.gov/NIOSH/npg/npgd0664.html.
  4. Food and Agricultural Organizations of the United Nations, “Turpentine from Pine Resin,” Chapter 8, Flavors and Fragrances of Plant Origin, http://www.mekonginfo.org/assets/midocs/0003277-environment-flavours-and-fragances-of-plant-origin.pdf
  5. Volatile Organic Compounds (VOC’s), Volatile Organic Compounds’ Impact on Indoor Air Quality | US EPA
  6. Lim, S.K., Shin. H.S., Yoon, K.S., Kwak, S.J., et. al., “Risk Assessment of Volatile Organic Compounds Benzene, Toluene, Ethylbenzene, Xylene (BTEX) in Consumer Products,” Journal of Toxicology of Environmental Health, Volume 77, 22-24, 2014, pages 1502-21.
  7. “Hazardous Substance Fact Sheet – Isopropyl Alcohol,” NJ Department of Health, April 2011, Rev. Feb. 2016.


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